Overview

5-MAPB (hydrochloride), also known as N,α-dimethyl-5-benzofuranethanamine or 5-(2-methylaminopropyl)benzofuran, is a synthetic benzofuran categorized as an analytical reference standard . This product is supplied as a high-purity crystalline solid (≥98%) for use in forensic and clinical toxicology laboratories . As a bioisosteric analogue of amphetamine with a benzofuran ring system, it has been detected in seized samples suspected of containing novel psychoactive substances (NPS) .

Chemical & Physical Properties

The material presents as a crystalline solid, suitable for precise weighing and preparation of analytical solutions . For stock solution preparation, DMF and DMSO provide the highest solubility, with the salt also dissolving in ethanol and PBS (pH 7.2) . UV absorption maxima are reported at 246, 279, and 286 nm . XRPD and DSC/TGA analysis confirm the crystalline nature of the hydrochloride salt .

Primary Research Applications

5-MAPB is primarily utilized as a forensic toxicology standard for the identification and quantification of benzofuran-type NPS in seized materials and biological specimens . Its applications include method development and validation for LC-MS/MS, as well as metabolism studies and confirmatory analysis. Metabolism research has identified the N-demethyl metabolite 5-APB and a main metabolite, 3-carboxymethyl-4-hydroxy methamphetamine, as key urinary biomarkers . The compound is studied in human liver preparations (pHLM, S9 fraction) to identify targets for toxicological screening .

Storage & Stability

For optimal stability, the product should be stored in a freezer at -20°C in a tightly sealed container . Stock solutions in appropriate solvents can be stored below -20°C for up to one month or at -80°C for up to six months .

Closing Statement

This high-purity crystalline reference material is intended exclusively for in vitro laboratory use in forensic and analytical research. Researchers should consult the Certificate of Analysis (COA) for specific lot data and purity certification. All handling must be performed within a properly controlled professional laboratory environment in compliance with relevant regulations.

⚠️ DISCLAIMER:
This product is sold strictly for laboratory and research purposes only. It is NOT intended for human or veterinary consumption, diagnostic use, or any application involving living organisms. All customers must be qualified and trained laboratory professionals. Buyer assumes all responsibility for safe handling, storage, and legal compliance in accordance with their local, state, and federal regulations. Always use appropriate personal protective equipment (PPE) and work within a properly ventilated fume hood.