Overview

5F-MDMB-PICA, also known as 5F-MDMB-2201 or 5-fluoro MDMB-2201, is a synthetic cannabinoid belonging to the indole-3-carboxamide class . This product is supplied as a high-purity (≥98%) analytical reference standard (CRM) for use in forensic and clinical toxicology laboratories . As a potent synthetic cannabinoid receptor agonist (SCRA) that has been identified in powders and herbal incenses, it serves as a critical reference material for the identification and quantification of this compound in seized materials and biological specimens .

Chemical & Physical Properties

The material typically presents as a white to off-white powder . For analytical preparation, stock solutions are commonly prepared in methanol, acetonitrile, or DMSO, making it suitable for LC-MS/MS and GC-MS workflows . Certified reference materials are manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards.

Primary Research Applications

5F-MDMB-PICA is primarily utilized as a certified reference standard for the identification and quantification of this indole-based synthetic cannabinoid in forensic toxicology and clinical research . Its primary applications include method development and validation for LC-MS/MS and GC-MS, as well as confirmatory analysis of biological specimens in urine drug testing and forensic casework . Metabolism research has established that the parent compound is rapidly metabolized via ester hydrolysis to its primary urinary biomarker, 5F-MDMB-PICA-COOH (metabolite 7), which is detected at concentrations orders of magnitude higher than the parent drug in urine . The parent compound exhibits significant instability in stored serum samples, degrading by over 94% after one year of storage, making metabolite-based analysis the preferred approach for forensic confirmation .

Storage & Stability

For optimal stability, the product should be stored in a freezer in a tightly sealed container . Certified reference material solutions should be handled promptly after opening to maintain accurate concentration. Researchers must adhere to standard safe handling practices for hazardous chemicals and maintain appropriate security for controlled substances.

Closing Statement

This high-purity certified reference material is intended exclusively for in vitro laboratory use in forensic and analytical research. Researchers should consult the Certificate of Analysis (COA) for specific lot data and certified purity values. All handling must be performed within a properly controlled professional laboratory environment, and users must ensure compliance with all local and federal regulations regarding synthetic cannabinoids.

⚠️ DISCLAIMER:
This product is sold strictly for laboratory and research purposes only. It is NOT intended for human or veterinary consumption, diagnostic use, or any application involving living organisms. All customers must be qualified and trained laboratory professionals. Buyer assumes all responsibility for safe handling, storage, and legal compliance in accordance with their local, state, and federal regulations. Always use appropriate personal protective equipment (PPE) and work within a properly ventilated fume hood.