Overview

Clonazolam, also known as clonitrazolam, is a designer benzodiazepine belonging to the triazolobenzodiazepine class of compounds . This product is supplied as a high-purity powder for use as an analytical reference standard in forensic and clinical toxicology laboratories . As a highly potent benzodiazepine analog encountered in forensic casework and seized materials, it serves as an essential reference material for the identification and quantification of these compounds in biological specimens and tablet formulations .

Chemical & Physical Properties

The material presents as a white to off-white powder . For analytical preparation, stock solutions are commonly prepared in acetonitrile or methanol, making it suitable for LC/MS and GC/MS workflows . Certified reference material solutions are available at a concentration of 1 mg/mL in acetonitrile for direct use in analytical applications .

Primary Research Applications

Clonazolam powder is primarily utilized as a forensic toxicology standard for the identification and quantification of designer benzodiazepines in biological matrices and seized materials . Its applications include method development and validation for LC-MS/MS and GC-MS, as well as confirmatory analysis of biological specimens in clinical toxicology and urine drug testing . The compound’s primary metabolite, 8-aminoclonazolam, has been identified as a major urinary biomarker, making it crucial for laboratories involved in confirmatory analysis and metabolism research . Stable-labeled internal standards, such as Clonazolam-d4, are available for quantitative analysis to ensure accuracy in LC/MS or GC/MS methods .

Storage & Stability

For optimal stability, the product should be stored frozen (-20°C) in a tightly sealed container . Certified reference material solutions in acetonitrile should be handled promptly after opening to maintain accurate concentration. Researchers must adhere to standard safe handling practices for hazardous chemicals and maintain appropriate security for controlled substances.

Closing Statement

This high-purity reference material is intended exclusively for in vitro laboratory use in forensic and analytical research. Researchers should consult the Certificate of Analysis (COA) for specific lot data and purity certification. All handling must be performed within a properly controlled professional laboratory environment, and users must ensure compliance with all local and federal regulations regarding designer benzodiazepines.

⚠️ DISCLAIMER:
This product is sold strictly for laboratory and research purposes only. It is NOT intended for human or veterinary consumption, diagnostic use, or any application involving living organisms. All customers must be qualified and trained laboratory professionals. Buyer assumes all responsibility for safe handling, storage, and legal compliance in accordance with their local, state, and federal regulations. Always use appropriate personal protective equipment (PPE) and work within a properly ventilated fume hood.