Overview

Butylone hydrochloride, also known as β-keto-N-methylbenzodioxolylbutanamine or bk-MBDB, is a synthetic cathinone analytical reference standard belonging to the β-keto amphetamine class. This product is supplied as a high-purity crystalline material for use in forensic and clinical toxicology laboratories. As the α-ethyl homolog within the methylone series, positioned between methylone (α-methyl) and pentylone (α-propyl), it serves as an essential reference material for the identification and quantification of cathinone derivatives in seized materials and biological specimens. The crystalline form offers advantages in terms of stability and precise weighing for analytical method development.

Chemical & Physical Properties

The material presents as an off-white to white crystalline solid with a melting point of 243.6°C for the hydrochloride salt. The crystalline morphology provides enhanced stability and handling characteristics, allowing for accurate weighing and preparation of analytical solutions. For analytical preparation, stock solutions are commonly prepared in methanol at certified concentrations of 1.0 mg/mL, making it suitable for LC-MS/MS and GC-MS workflows. Certified reference materials are available as DEA-exempt preparations for streamlined laboratory ordering.

Primary Research Applications

Butylone crystal is primarily utilized as a forensic toxicology standard for the identification and quantification of cathinone derivatives in biological matrices and seized materials. Its applications include method development and validation for LC-MS/MS and GC-MS, as well as confirmatory analysis of biological specimens in clinical toxicology and urine drug testing. The compound serves as a standard for metabolism research, with studies identifying N-demethylation, β-ketone reduction, demethylenation followed by O-methylation, and glucuronide conjugation as primary metabolic pathways. Key urinary biomarkers include hydroxylated and O-methylated metabolites from the demethylenation pathway. Deuterated internal standards such as butylone-D3 HCl are available for accurate quantification via isotope dilution mass spectrometry.

Storage & Stability

For optimal stability, the product should be stored in a freezer in a tightly sealed container. The crystalline material has demonstrated stability over a minimum period of ten years when stored at or below 25°C in a closed container in a dry, dark area. Protection from light is recommended to prevent degradation. Researchers must adhere to standard safe handling practices for hazardous chemicals and maintain appropriate security for controlled substances.

Closing Statement

This high-purity crystalline certified reference material is intended exclusively for in vitro laboratory use in forensic and analytical research. Researchers should consult the Certificate of Analysis (COA) for specific lot data and certified purity values. All handling must be performed within a properly controlled professional laboratory environment, and users must ensure compliance with all local and federal regulations regarding synthetic cathinones.

⚠️ DISCLAIMER:
This product is sold strictly for laboratory and research purposes only. It is NOT intended for human or veterinary consumption, diagnostic use, or any application involving living organisms. All customers must be qualified and trained laboratory professionals. Buyer assumes all responsibility for safe handling, storage, and legal compliance in accordance with their local, state, and federal regulations. Always use appropriate personal protective equipment (PPE) and work within a properly ventilated fume hood.