Overview

Carfentanil, also known as 4-carbomethoxyfentanyl, is a synthetic opioid belonging to the 4-anilidopiperidine class of fentanyl analogues . This product is supplied as a high-purity certified reference material (CRM) for use in forensic and clinical toxicology laboratories . As a Schedule II controlled substance, it serves as an essential reference standard for the identification and quantification of this extremely potent synthetic opioid in seized materials and biological specimens. Carfentanil was originally developed for veterinary use as a tranquilizer for large animals and has an estimated potency approximately ten thousand times that of morphine .

Chemical & Physical Properties

The material typically presents as a white to off-white powder or crystalline solid . For analytical preparation, stock solutions are commonly prepared in methanol, making it suitable for LC-MS/MS and GC-MS workflows . The compound is highly lipophilic with a reported logP of 3.85 and a pKa of approximately 8.10 .

Primary Research Applications

Carfentanil is primarily utilized as a certified reference standard for the identification and quantification of this fentanyl analogue in forensic toxicology and clinical research . Its primary applications include method development and validation for LC-MS/MS and GC-MS, as well as confirmatory analysis of biological specimens in urine drug testing and forensic casework . The compound has been identified as an adulterant in heroin and has been linked to emergency room visits and fatalities . Stable-labeled internal standards, such as carfentanil-D5 or carfentanil-13C6, are available for quantitative analysis to ensure accuracy in LC/MS or GC/MS methods .

Storage & Stability

For optimal stability, the product should be stored frozen in a tightly sealed container . Due to the extreme acute toxicity of carfentanil, special security measures are required, including storage in a safe or steel cabinet equivalent to a U.S. Government Class V security container . The antidote naloxone should be readily available to personnel, and resuscitation training should be provided . Certified reference material solutions should be handled promptly after opening to maintain accurate concentration. Researchers must adhere to standard safe handling practices for hazardous chemicals and maintain appropriate security for controlled substances.

Closing Statement

This high-purity certified reference material is intended exclusively for in vitro laboratory use in forensic and analytical research. Researchers should consult the Certificate of Analysis (COA) for specific lot data and certified purity values . All handling must be performed within a properly controlled professional laboratory environment, and users must ensure compliance with all local and federal regulations regarding controlled substances.

⚠️ DISCLAIMER:
This product is sold strictly for laboratory and research purposes only. It is NOT intended for human or veterinary consumption, diagnostic use, or any application involving living organisms. All customers must be qualified and trained laboratory professionals. Buyer assumes all responsibility for safe handling, storage, and legal compliance in accordance with their local, state, and federal regulations. Always use appropriate personal protective equipment (PPE) and work within a properly ventilated fume hood.