Overview

Cocaine hydrochloride is a tropane alkaloid analytical reference standard extracted from the leaves of Erythroxylum coca and related species native to the Andean region of South America . This product is supplied as a high-purity crystalline solid for use in forensic and clinical toxicology laboratories. As a Schedule II controlled substance, it serves as an essential reference material for the identification, quantification, and profiling of cocaine in seized materials and biological specimens. The term “Colombian” reflects the geographic origin of the coca leaf used in production, which influences the compound’s minor alkaloid profile and impurity signature .

Chemical & Physical Properties

The material presents as a white to off-white crystalline powder with a melting point of 96-98°C (free base) and 195-198°C (hydrochloride salt) . It exhibits a specific optical rotation of -79 to -81° in 0.1M hydrochloric acid . The compound displays UV absorption maxima at 231 nm, useful for detection in analytical workflows .

Primary Research Applications

Cocaine hydrochloride is primarily utilized as a certified reference material for the identification and quantification of cocaine in forensic toxicology and clinical research . Its primary applications include method development and validation for LC-MS/MS, HPLC, and GC-MS, as well as confirmatory analysis of biological specimens in urine drug testing and forensic casework . The compound also serves as a standard for cocaine profiling studies, where minor alkaloid ratios (tropacocaine, trimethoxycocaine, truxillines, and cinnamoylcocaines) are used to determine the geographic origin of cocaine samples, distinguishing Colombian-produced material from Bolivian or Peruvian sources . Analytical standards typically exceed 98% purity and are tested under ISO/IEC 17025 accreditation .

Storage & Stability

For optimal stability, the product should be stored frozen or at room temperature below 25°C in a tightly sealed, light-resistant container . The material is hygroscopic to some extent and should be stored desiccated. Certified reference material solutions should be handled promptly after opening to maintain accurate concentration . Researchers must adhere to standard safe handling practices for hazardous chemicals and maintain appropriate security for controlled substances .

Closing Statement

This high-purity certified reference material is intended exclusively for in vitro laboratory use in forensic and analytical research. Researchers should consult the Certificate of Analysis (COA) for specific lot data and certified purity values . All handling must be performed within a properly controlled professional laboratory environment, and users must ensure compliance with all local and federal regulations regarding controlled substances .

⚠️ DISCLAIMER:
This product is sold strictly for laboratory and research purposes only. It is NOT intended for human or veterinary consumption, diagnostic use, or any application involving living organisms. All customers must be qualified and trained laboratory professionals. Buyer assumes all responsibility for safe handling, storage, and legal compliance in accordance with their local, state, and federal regulations. Always use appropriate personal protective equipment (PPE) and work within a properly ventilated fume hood.