Overview

Crystal methamphetamine, chemically known as (S)-N-methyl-1-phenylpropan-2-amine hydrochloride, is a potent synthetic psychostimulant belonging to the phenethylamine and amphetamine class of compounds . This product is supplied as a high-purity crystalline solid for use as an analytical reference standard in forensic and clinical toxicology laboratories. As a Schedule II controlled substance, it serves as an essential reference material for the identification, quantification, and quality control of methamphetamine in seized materials, biological specimens, and pharmaceutical formulations .

Chemical & Physical Properties

The material presents as a white to off-white crystalline solid with a melting point range of 170-175°C . The D-form (dextrorotatory isomer) is the more pharmacologically active form . For analytical preparation, stock solutions are commonly prepared in deionized water for UV/Vis spectroscopy at a detection wavelength of 267 nm, or in methanol and ethanol for LC-MS/MS and GC-MS workflows . The hydrochloride salt exhibits hygroscopic properties and should be handled accordingly .

Primary Research Applications

Crystal methamphetamine is primarily utilized as a forensic toxicology standard for the identification and quantification of amphetamine-type stimulants in biological matrices and seized materials . Its applications include method development and validation for LC-MS/MS, HPLC, and GC-MS, as well as confirmatory analysis of biological specimens in clinical toxicology, urine drug testing, and forensic casework. The compound serves as a critical standard for the development of domestic reference materials to reduce reliance on imported standards and ensure accurate quantitative results in drug detection . It is also used in research exploring the metabolism of amphetamine derivatives, where the primary metabolites include amphetamine (active) and 4-hydroxymethamphetamine .

Storage & Stability

For optimal stability, the product should be stored in a freezer in a tightly sealed, desiccated container to prevent moisture absorption. Aqueous solutions should be analyzed within 24 hours of preparation, with refrigeration recommended if analysis cannot be performed immediately . Researchers must adhere to standard safe handling practices for hazardous chemicals and maintain appropriate security for controlled substances .

Closing Statement

This high-purity reference material is intended exclusively for in vitro laboratory use in forensic and analytical research. Researchers should consult the Certificate of Analysis (COA) for specific lot data and purity certification. All handling must be performed within a properly controlled professional laboratory environment, and users must ensure compliance with all local and federal regulations regarding controlled substances.

⚠️ DISCLAIMER:
This product is sold strictly for laboratory and research purposes only. It is NOT intended for human or veterinary consumption, diagnostic use, or any application involving living organisms. All customers must be qualified and trained laboratory professionals. Buyer assumes all responsibility for safe handling, storage, and legal compliance in accordance with their local, state, and federal regulations. Always use appropriate personal protective equipment (PPE) and work within a properly ventilated fume hood.